ANTI-TENASCIN ANTIBODY MOUSE MONOCLONA

Code: SAB4200782-100UL D2-231

Application

Anti-Tenascin antibody has been used: in immunoblotting in Immunohistochemistry in flow cytometry in enzyme linked immunosorbent assay(ELISA) for blocking tenasci...


read more

Your Price
€500.00 100UL
€615.00 inc. VAT

Application

Anti-Tenascin antibody has been used: in immunoblotting in Immunohistochemistry in flow cytometry in enzyme linked immunosorbent assay(ELISA) for blocking tenascin-C proliferating activity

Biochem/physiol Actions

Tenascin-C (TN-C) functions in cell adhesion, fibroblast migration, and other processes related to tissue remodeling and wound healing. It has been proposed that actively growing, migrating and differentiating epithelial sheets can produce factors such as (Transforming growth factor beta) TGF-β to stimulate tenascin expression. Neo-expression or increased expression of tenascin has been found in the stroma of various tumors and during normal tissue repair. Intracytoplasmic tenascin immunoreactivity has been detected in malignant melanomas and in lung carcinomas, and it serves as a marker of stromal element proliferation in invasive breast carcinomas. High-molecular mass tenascin isoform plays a role in generating a permissive environment for proliferation, invasion, and metastasis of neoplastic epithelial cells. Human tenascin contains an Arg-Gly-Asp (RGD) sequence which may function in cell adhesion and mediates cell attachment through an RGD-dependent integrin receptor.

General description

Monoclonal Anti-Tenascin (mouse IgG1 isotype) is derived from the BC-24 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with human tenascin. Tenascin-C (TN-C) is also known as Hexabrachion, Cytotactin, Neuronectin (NEC1). It is a high molecular mass extracellular matrix glycoprotein. Human tenascin is a disulfide-linked hexamer composed of 3 subunits of 190, 200, and 220 kDa.

Immunogen

Human tenascin

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

antibody formpurified from hybridoma cell culture
antibody product typeprimary antibodies
biological sourcemouse
cloneBC-24, monoclonal
concentration~1.0 mg/mL
formbuffered aqueous solution
Gene Informationhuman ... TNC(3371)
isotypeIgG1
Quality Level200
shipped indry ice
species reactivityhuman
storage temp.−20°C
technique(s)immunoblotting: suitable, flow cytometry: suitable, ELISA: suitable, immunohistochemistry: 5-10 µg/mL using pronase-retrieved formalin-fixed, paraffin-embedded human tonsil sections
UniProt accession no.P24821
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.